Minimizing the number of optimizations for efficient community dynamic flux balance analysis.

ABSTRACT: Dynamic flux balance analysis uses a quasi-steady state assumption to calculate an organism's metabolic activity at each time-step of a dynamic simulation, using the well-known technique of flux balance analysis. For microbial communities, this calculation is especially costly and involves solving a linear constrained optimization problem for each member of the community at each time step. However, this is unnecessary and inefficient, as prior solutions can be used to inform future time steps. Here, we show that a basis for the space of internal fluxes can be chosen for each microbe in a community and this basis can be used to simulate forward by solving a relatively inexpensive system of linear equations at most time steps. We can use this solution as long as the resulting metabolic activ

SUBMITTER: Brunner JD 

PROVIDER: S-EPMC7546477 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature