Antibody responses to SARS-CoV-2 in patients with differing severities of coronavirus disease 2019.

ABSTRACT:

Background

A greater understanding of the antibody response to SARS-CoV-2 in an infected population is important for the development of a vaccination.

Aim

To investigate SARS-CoV-2 IgA and IgG antibodies in Thai patients with differing severities of COVID-19.

Methods

Plasma from the following patient groups was examined: 118 adult patients with confirmed SARS-CoV-2 infections, 49 patients under investigation (without confirmed infections), 20 patients with other respiratory infections, and 102 healthy control patients. Anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) from EUROIMMUN was performed to assess for IgA and IgG antibodies. The optical density (OD) ratio cutoff for a positive result was 1.1 for IgA and 0.8 for IgG. Additionally, the association of th

SUBMITTER: Kowitdamrong E 

PROVIDER: S-EPMC7546485 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature