Biodegradable fluorescent nanoparticles for endoscopic detection of colorectal carcinogenesis.

ABSTRACT: Early and comprehensive endoscopic detection of colonic dysplasia - the most clinically significant precursor lesion to colorectal adenocarcinoma - provides an opportunity for timely, minimally-invasive intervention to prevent malignant transformation. Here, the development and evaluation of biodegradable near-infrared fluorescent silica nanoparticles (FSN) is described that have the potential to improve adenoma detection during fluorescence-assisted white-light colonoscopic surveillance in rodent and human-scale models of colorectal carcinogenesis. FSNs are biodegradable (t1/2 of 2.7 weeks), well-tolerated, and enable detection and delineation of adenomas as small as 0.5 mm2 with high tumor-to-background ratios. Furthermore, in the human-scale, APC1311/+ porcine model, the clinical feasib

SUBMITTER: Rogalla S 

PROVIDER: S-EPMC7546531 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature