Comparative gender peptidomics of Bothrops atrox venoms: are there differences between them?

ABSTRACT:

Background

Bothrops atrox is known to be the pit viper responsible for most snakebites and human fatalities in the Amazon region. It can be found in a wide geographical area including northern South America, the east of Andes and the Amazon basin. Possibly, due to its wide distribution and generalist feeding, intraspecific venom variation was reported by previous proteomics studies. Sex-based and ontogenetic variations on venom compositions of Bothrops snakes were also subject of proteomic and peptidomic analysis. However, the venom peptidome of B. atrox remains unknown.

Methods

We conducted a mass spectrometry-based analysis of the venom peptides of individual male and female specimens combining bottom-up and top-down approaches.

Results

We ident

SUBMITTER: Simizo A 

PROVIDER: S-EPMC7546584 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature