The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein.

ABSTRACT: HIV-1 Tat is a potent neurotoxic protein that is released by HIV-1 infected cells in the brain and perturbs neuronal homeostasis, causing a broad range of neurological disorders in people living with HIV-1. Furthermore, the effects of Tat have been addressed in numerous studies to investigate the molecular events associated with neuronal cells survival and death. Here, we discovered that exposure of rat primary neurons to Tat resulted in the up-regulation of an uncharacterized long non-coding RNA (lncRNA), LOC102549805 (lncRNA-U1). Our observations showed that increased expression of lncRNA-U1 in neurons disrupts bioenergetic pathways by dysregulating homeostasis of Ca²⁺, mitigating mitochondrial oxygen reduction, and decreasing ATP production, all of which point mitochondrial i

SUBMITTER: Torkzaban B 

PROVIDER: S-EPMC7546609 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature