Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.

ABSTRACT: Honey bees (Apis mellifera L.) suffer from many brood pathogens, including viruses. Despite considerable research, the molecular responses and dynamics of honey bee pupae to viral pathogens remain poorly understood. Israeli Acute Paralysis Virus (IAPV) is emerging as a model virus since its association with severe colony losses. Using worker pupae, we studied the transcriptomic and methylomic consequences of IAPV infection over three distinct time points after inoculation. Contrasts of gene expression and 5 mC DNA methylation profiles between IAPV-infected and control individuals at these time points - corresponding to the pre-replicative (5 h), replicative (20 h), and terminal (48 h) phase of infection - indicate that profound immune responses and distinct manipulation of host mole

SUBMITTER: Li-Byarlay H 

PROVIDER: S-EPMC7546774 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature