The CD133⁺ Stem/Progenitor-Like Cell Subset Is Increased in Human Milk and Peripheral Blood of HIV-Positive Women.

ABSTRACT: Human milk is a significant source of different CD133⁺ and/or CD34⁺ stem/progenitor-like cell subsets in healthy women but their cell distribution and percentages in this compartment of HIV-positive women have not been explored. To date, a decrease of CD34⁺ hematopoietic stem and progenitor cell frequencies in peripheral blood and bone marrow of HIV-positive patients has been reported. Herein, human milk and peripheral blood samples were collected between day 2-15 post-partum from HIV-positive and HIV-negative women, and cells were stained with stem cell markers and analyzed by flow cytometry. We report that the median percentage of CD45^+/highCD34^-CD133⁺ cell subset from milk and blood was significantly higher in HIV-positiv

SUBMITTER: Valverde-Villegas JM 

PROVIDER: S-EPMC7546783 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature