Incidence and frequency of cancer cachexia during chemotherapy for advanced pancreatic ductal adenocarcinoma.

ABSTRACT:

Purpose

Cachexia influences the patient's physical wellbeing and quality of life, and the patient's ability to tolerate their cancer therapies, especially cytotoxic chemotherapy. The purpose of this study was to investigate the frequency and timing of onset of cancer cachexia during chemotherapy and its association with prognosis and toxicity in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods

We performed a retrospective study in patients who underwent first-line chemotherapy after diagnosis of advanced PDAC between 6 June 2008 and 31 March 2017. Base cachexia (weight loss up to 6 months before starting first-line chemotherapy) and follow-up cachexia (after starting first-line chemotherapy) were defined as weight loss > 2% with a body mass index (BMI) < 20 kg/

SUBMITTER: Mitsunaga S 

PROVIDER: S-EPMC7546994 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature