The vitamin D for COVID-19 (VIVID) trial: A pragmatic cluster-randomized design.

ABSTRACT:

Objectives

To determine the effect of vitamin D supplementation on disease progression and post-exposure prophylaxis for COVID-19 infection. We hypothesize that high-dose vitamin D3 supplementation will reduce risk of hospitalization/death among those with recently diagnosed COVID-19 infection and will reduce risk of COVID-19 infection among their close household contacts.

Methods

We report the rationale and design of a planned pragmatic, cluster randomized, double-blinded trial (N = 2700 in total nationwide), with 1500 newly diagnosed individuals with COVID-19 infection, together with up to one close household contact each (~1200 contacts), randomized to either vitamin D3 (loading dose, then 3200 IU/day) or placebo in a 1:1 ratio and a household cluster design. The study du

SUBMITTER: Wang R 

PROVIDER: S-EPMC7547023 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature