Dopamine D2 receptor signaling on iMSNs is required for initiation and vigor of learned actions.

ABSTRACT: Striatal dopamine D2 receptors (D2Rs) are important for motor output. Selective deletion of D2Rs from indirect pathway-projecting medium spiny neurons (iMSNs) impairs locomotor activities in a task-specific manner. However, the role of D2Rs in the initiation of motor actions in reward seeking and taking is not fully understood, and there is little information about how receptors contribute under different task demands and with different outcome types. The iMSN-D2Rs modulate neuronal activity and synaptic transmission, exerting control on circuit functions that may play distinct roles in action learning and performance. Selective deletion of D2Rs on iMSNs resulted in slower action initiation and response rate in an instrumental conditioning task, but only when performance demand was increas

SUBMITTER: Augustin SM 

PROVIDER: S-EPMC7547091 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature