Hazards and risk assessment of heavy metals from consumption of locally manufactured painkiller drugs in Nigeria.

ABSTRACT: In the informal sector of Nigeria's economy, jobs are done manually as against automation resulting in body stress and pain, hence the need for painkiller drugs. Thirty different locally manufactured painkiller drugs, with analgesic, antipyretic and anti-inflammatory effects, were randomly sampled from pharmaceutical shops within Awka in October 2016. The drugs were pulverised, sieved and ashed before digestion using conc aqua regia HCl : HNO₃ (3:1), carcinogenic heavy metals (arsenic, cadmium, chromium, mercury, nicked and lead) were assayed using Varian AA240 atomic absorption spectrophotometer (AAS). Risk assessment was carried out using US EPA model. The highest levels of arsenic (0.350 mg/kg) were found in samples with code 01, 03 and 020, cadmium (0.107 mg/kg and 0.144 mg/

SUBMITTER: Nduka JK 

PROVIDER: S-EPMC7547146 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature