Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder.

ABSTRACT: Major depressive disorder emerges from the complex interactions of biological systems that span genes and molecules through cells, networks, and behavior. Establishing how neurobiological processes coalesce to contribute to depression requires a multiscale approach, encompassing measures of brain structure and function as well as genetic and cell-specific transcriptional data. Here, we examine anatomical (cortical thickness) and functional (functional variability, global brain connectivity) correlates of depression and negative affect across three population-imaging datasets: UK Biobank, Brain Genomics Superstruct Project, and Enhancing NeuroImaging through Meta Analysis (ENIGMA; combined n ≥ 23,723). Integrative analyses incorporate measures of cortical gene expression, postmortem

SUBMITTER: Anderson KM 

PROVIDER: S-EPMC7547155 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature