Fecal Microbiota Alterations and Small Intestinal Bacterial Overgrowth in Functional Abdominal Bloating/Distention.

ABSTRACT:

Background/aims

The pathophysiology of functional abdominal bloating and distention (FABD) is unclear yet. Our aim is to compare the diversity and composition of fecal microbiota in patients with FABD and healthy individuals, and to evaluate the relationship between small intestinal bacterial overgrowth (SIBO) and dysbiosis.

Methods

The microbiota of fecal samples was analyzed from 33 subjects, including 12 healthy controls and 21 patients with FABD diagnosed by the Rome IV criteria. FABD patients underwent a hydrogen breath test. Fecal microbiota composition was determined by 16S ribosomal RNA amplification and sequencing.

Results

Overall fecal microbiota composition of the FABD group differed from that of the control group. Microbial diversity was significantly lowe

SUBMITTER: Noh CK 

PROVIDER: S-EPMC7547202 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature