Transcription factor expression defines subclasses of developing projection neurons highly similar to single-cell RNA-seq subtypes.

ABSTRACT: We are only just beginning to catalog the vast diversity of cell types in the cerebral cortex. Such categorization is a first step toward understanding how diversification relates to function. All cortical projection neurons arise from a uniform pool of progenitor cells that lines the ventricles of the forebrain. It is still unclear how these progenitor cells generate the more than 50 unique types of mature cortical projection neurons defined by their distinct gene-expression profiles. Moreover, exactly how and when neurons diversify their function during development is unknown. Here we relate gene expression and chromatin accessibility of two subclasses of projection neurons with divergent morphological and functional features as they develop in the mouse brain between embryonic day 13 an

SUBMITTER: Heavner WE 

PROVIDER: S-EPMC7547209 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature