Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice.

ABSTRACT: Influenza A virus (IAV) infection during pregnancy causes severe maternal and perinatal complications, despite a lack of vertical transmission of IAV across the placenta. Here, we demonstrate a significant alteration in the maternal vascular landscape that underpins the maternal and downstream fetal pathology to IAV infection in mice. In IAV infection of nonpregnant mice, the local lung inflammatory response was contained to the lungs and was self-resolving, whereas in pregnant mice, virus dissemination to major maternal blood vessels, including the aorta, resulted in a peripheral "vascular storm," with elevated proinflammatory and antiviral mediators and the influx of Ly6C^low and Ly6C^high monocytes, plus neutrophils and T cells. This vascular storm was associated wit

SUBMITTER: Liong S 

PROVIDER: S-EPMC7547222 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature