Non-ionic CT contrast solutions rapidly alter bovine cartilage and meniscus mechanics.

ABSTRACT:

Objective

To evaluate effects of a common CT contrast agent (iohexol) on the mechanical behaviors of cartilage and meniscus.

Methods

Indentation responses of juvenile bovine cartilage and meniscus were monitored following exposure to undiluted contrast agent (100% CA), 50% CA/water, 50% CA/Phosphate Buffered Saline (PBS) or PBS alone, and during re-equilibration in PBS. The normalized peak force (F_pk¯), effective osmotic strain (ε_osm), and normalized effective contact modulus (E_c¯) were calculated for every cycle, with time constants determined for both exposure and recovery via mono- or biexponential fits to F_pk¯.

Results

All cartilage CA groups exhibited long-term increases in F_pk¯ following exposure, although t

SUBMITTER: Baylon EG 

PROVIDER: S-EPMC7547404 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature