The reductive glycine pathway allows autotrophic growth of Desulfovibrio desulfuricans.

ABSTRACT: Six CO₂ fixation pathways are known to operate in photoautotrophic and chemoautotrophic microorganisms. Here, we describe chemolithoautotrophic growth of the sulphate-reducing bacterium Desulfovibrio desulfuricans (strain G11) with hydrogen and sulphate as energy substrates. Genomic, transcriptomic, proteomic and metabolomic analyses reveal that D. desulfuricans assimilates CO₂ via the reductive glycine pathway, a seventh CO₂ fixation pathway. In this pathway, CO₂ is first reduced to formate, which is reduced and condensed with a second CO₂ to generate glycine. Glycine is further reduced in D. desulfuricans by glycine reductase to acetyl-P, and then to acetyl-CoA, which is condensed with another CO₂ to form pyruvate. Ammonia

SUBMITTER: Sanchez-Andrea I 

PROVIDER: S-EPMC7547702 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature