A broad diversity in oxygen affinity to haemoglobin.

ABSTRACT: Oxygen affinity to haemoglobin is indicated by the p50 value (pO₂ at 50% O₂Hb) and critically determines cellular oxygen availability. Although high Hb-O₂ affinity can cause tissue hypoxia under conditions of well O₂ saturated blood, individual differences in p50 are commonly not considered in clinical routine. Here, we investigated the diversity in Hb-O₂ affinity in the context of physiological relevance. Oxyhaemoglobin dissociation curves (ODCs) of 60 volunteers (18-40 years, both sexes, either endurance trained or untrained) were measured at rest and after maximum exercise (VO₂max) test. At rest, p50 values of all participants ranged over 7 mmHg. For comparison, right shift of ODC after VO₂max test, representin

SUBMITTER: Balcerek B 

PROVIDER: S-EPMC7547706 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature