Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico.

ABSTRACT:

Purpose

This study aimed to analyze the association of the apolipoprotein E (ApoE) polymorphisms with type 2 diabetes mellitus (T2DM) among the admixed population of West Mexico.

Patients and methods

ApoE genotypes were determined in 168 T2DM patients and 449 non-diabetic control subjects from the general admixed population of West Mexico. The non-diabetic subjects were stratified according to body mass index (BMI) in normal weight (n=186), overweight (n=138), and obesity (n=125). ApoE genotypes were assessed by using a TaqMan allelic discrimination assay, insulin resistance (IR) by HOMA-IR, and biochemistry with a dry chemistry assay.

Results

The rate of dyslipidemias and IR increased by BMI category among the control subjects. The greater shift

SUBMITTER: Gonzalez-Aldaco K 

PROVIDER: S-EPMC7547770 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature