Automated in-process characterization and selection of cell-clones for quality and efficient cell manufacturing.

ABSTRACT: Delivery of safe, effective and reliable cellular therapies, whether based on mesenchymal stromal cells (MSCs) or induced pluripotent stem cells (iPSCs), demand standardization of cell culture protocols. There is a need to develop automation platform that enables the users to generate culture expanded human cell populations that improves the quality and reduces batch-to-batch variation with respect to biological potential. Cell X™ robot was designed to address these current challenges in the cell fabrication industry. It utilizes non-invasive large field of view quantitative image analysis to guide an automated process of targeted "biopsy" (cells or media), "picking" (selection) of desired cells or colonies, or "weeding" (removal) of undesired cells, thus providing an unprecedented ability

SUBMITTER: Mantripragada VP 

PROVIDER: S-EPMC7547927 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature