Insights from VERIFY: Early Combination Therapy Provides Better Glycaemic Durability Than a Stepwise Approach in Newly Diagnosed Type 2 Diabetes.

ABSTRACT: The treatment aims for type 2 diabetes are to prevent complications and premature mortality, and improve quality of life. Glycaemic control is central to these aims; clinical guidelines have sought to achieve this with a stepwise approach starting with lifestyle measures and metformin, adding further medications once glycated haemoglobin (HbA_1c) levels rise above a predefined threshold. However, treatment intensification can be delayed when HbA_1c levels increase, and HbA_1c levels become inadequately controlled in many patients. Clinical inertia can result in sustained elevated levels of HbA_1c; when combined with a late diagnosis, this negatively impacts patients' prognosis. Early combination therapy using medications with complementary modes of a

SUBMITTER: Matthews D 

PROVIDER: S-EPMC7547931 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature