The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID-19.

ABSTRACT:

Background

COVID-19 is currently a global pandemic, but the response of human immune system to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unclear. Noncoding RNAs serve as immune regulators and thus may play a critical role in disease progression.

Methods

We performed multi-transcriptome sequencing of both noncoding RNAs and mRNAs isolated from the red blood cell depleted whole blood of moderate and severe COVID-19 patients. The functions of noncoding RNAs were validated by analyses of the expression of downstream mRNAs. We further utilized the single-cell RNA-seq data of COVID-19 patients from Wilk et al. and Chua et al. to characterize noncoding RNA functions in different cell types.

Results

We defined four types of microRNAs with

SUBMITTER: Tang H 

PROVIDER: S-EPMC7548099 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature