Detailed functional and structural characterization of a macular lesion in a rhesus macaque.

ABSTRACT:

Purpose

Animal models are powerful tools to broaden our understanding of disease mechanisms and to develop future treatment strategies. Here we present detailed structural and functional findings of a rhesus macaque suffering from a naturally occurring bilateral macular dystrophy (BMD), partial optic atrophy and corresponding reduction of central V1 signals in visual fMRI experiments when compared to data in a healthy macaque (CTRL) of similar age.

Methods

Retinal imaging included infrared and autofluorescence recordings, fluorescein and indocyanine green angiography and spectral domain optical coherence tomography (OCT) on the Spectralis HRA + OCT platform. Electroretinography included multifocal and Ganzfeld-ERG recordings. Animals were killed and eyes analyzed by immunohi

SUBMITTER: Dominik Fischer M 

PROVIDER: S-EPMC7548104 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature