Anti-metastatic action of an N ⁴-aryl substituted thiosemicarbazone on advanced triple negative breast cancer.

ABSTRACT:

Purpose

Advanced triple negative breast cancer (ATNBC) is defined by a lack of expression of hormones receptors as well as HER2/neu and its high probability of visceral metastasis. This pathology is associated with a poor prognosis. Previously, we found that T2, an N ⁴-arylsubstituted thiosemicarbazone (N ⁴-TSC), had cytotoxic effect on human breast cancer cells lines. Hence, in this study, we investigated the anti-metastasic action of T2 on ATNBC.

Methods

In order to deepen T2 action mode on ATNBC, we first confirmed T2 cytotoxicity on a panel of TNBC cells and then continued studying T2 effects in vitro an in vivo on the syngeneic 4T1 mouse model.

Results

We found that T2 had a cytotoxic effect comparable to chemothe

SUBMITTER: Solimo AM 

PROVIDER: S-EPMC7548444 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature