Ontology highlight
ABSTRACT: Background
Prior to the approval of sorafenib, hepatic arterial infusion chemotherapy (HAIC) was offered to patients with advanced hepatocellular carcinoma (HCC) in East Asia, particularly Japan. According to the Japanese guidelines, HAIC is recommended as one of the treatment options in patients without extrahepatic metastasis (EHM).Methods
The present cohort study compared the use of HAIC and sorafenib on outcomes of patients with advanced HCC. Consecutive patients with advanced HCC who received HAIC or sorafenib as a first-line systemic therapy were enrolled from 10 Japanese institutions. The primary outcomes were overall survival (OS) in patients with macrovascular invasion (MVI), but without EHM, and OS in patients without both MVI and EHM.Results
Between 2009 and 2016, 2,006 patients were enrolled (541 HAIC patients, 1,465 sorafenib patients). After propensity score matching, the OS of patients with MVI but without EHM was significantly longer in the HAIC group compared with the sorafenib group (10.1 vs. 9.1 months for the HAIC and sorafenib groups, respectively; n = 170 for each group; hazard ratio [HR] 0.668; 95% confidence interval [95% CI] 0.475-0.935; p = 0.018). There was no significant difference in OS between patients without both MVI and EHM (12.2 vs. 15.4 months for the HAIC and sorafenib groups, respectively; n = 76 in each cohort after propensity score matching; HR 1.227; 95% CI 0.699-2.155; p = 0.475).Conclusion
HAIC is a potential front-line treatment choice in a subpopulation of patients with advanced HCC with MVI but without EHM.
SUBMITTER: Ueshima K
PROVIDER: S-EPMC7548914 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Ueshima Kazuomi K Ogasawara Sadahisa S Ikeda Masafumi M Yasui Yutaka Y Terashima Takeshi T Yamashita Tatsuya T Obi Shuntaro S Sato Shinpei S Aikata Hiroshi H Ohmura Takumi T Kuroda Hidekatsu H Ohki Takamasa T Nagashima Kengo K Ooka Yoshihiko Y Takita Masahiro M Kurosaki Masayuki M Chayama Kazuaki K Kaneko Shuichi S Izumi Namiki N Kato Naoya N Kudo Masatoshi M Omata Masao M
Liver cancer 20200724 5
<h4>Background</h4>Prior to the approval of sorafenib, hepatic arterial infusion chemotherapy (HAIC) was offered to patients with advanced hepatocellular carcinoma (HCC) in East Asia, particularly Japan. According to the Japanese guidelines, HAIC is recommended as one of the treatment options in patients without extrahepatic metastasis (EHM).<h4>Methods</h4>The present cohort study compared the use of HAIC and sorafenib on outcomes of patients with advanced HCC. Consecutive patients with advance ...[more]