Urinary Apolipoprotein C3 Is a Potential Biomarker for Alzheimer's Disease.

ABSTRACT:

Introduction

Biomarkers of Alzheimer's disease (AD) that can easily be measured in routine health checkups are desirable. Urine is a source of biomarkers that can be collected easily and noninvasively. We previously reported on the comprehensive profile of the urinary proteome of AD patients and identified proteins estimated to be significantly increased or decreased in AD patients by a label-free quantification method. The present study aimed to validate urinary levels of proteins that significantly differed between AD and control samples from our proteomics study (i.e., apolipoprotein C3 [ApoC3], insulin-like growth factor-binding protein 3 [Igfbp3], and apolipoprotein D [ApoD]).

Methods

Enzyme-linked immunosorbent assays (ELISAs) were performed using urine samples from th

SUBMITTER: Watanabe Y 

PROVIDER: S-EPMC7548924 | biostudies-literature | 2020 Sep-Dec

REPOSITORIES: biostudies-literature