Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.

ABSTRACT: The nucleus of the solitary tract (NTS) is emerging as a major site of action for the appetite-suppressive effects of leading pharmacotherapies currently investigated to treat obesity. However, our understanding of how NTS neurons regulate appetite remains incomplete.

Objectives

In this study, we used NTS nutrient sensing as an entry point to characterize stimulus-defined neuronal ensembles engaged by the NTS to produce physiological satiety.

Methods

We combined histological analysis, neuroanatomical assessment using inducible viral tracing tools, and functional tests to characterize hindbrain-forebrain circuits engaged by NTS leucine sensing to suppress hunger.

Results

We found that NTS detection of leucine engages NTS prolactin-releasing peptide (PrRP) neurons to inh

SUBMITTER: Tsang AH 

PROVIDER: S-EPMC7549147 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature