Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most common cancers worldwide. Circular RNAs (circRNAs), a novel class of non-coding RNAs, have been confirmed to be key regulators of many diseases. With many scholars devoted to studying the biological function and mechanism of circRNAs, their mysterious veil is gradually being revealed. In our research, we explored a new circRNA, hsa_circ_0026416, which was identified as upregulated in CRC with the largest fold change (logFC = 3.70) of the evaluated circRNAs via analysing expression profiling data by high throughput sequencing of members of the GEO dataset (GSE77661) to explore the molecular mechanisms of CRC.

Methods

qRT-PCR and western blot analysis were utilized to assess the expression of hsa_circ_0026416, miR-346 and N

SUBMITTER: Liang Y 

PROVIDER: S-EPMC7549246 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature