Placental and Cord Blood Telomere Length in Relation to Maternal Nutritional Status.

ABSTRACT:

Background

The uterine environment may be important for the chromosomal telomere length (TL) at birth, which, in turn, influences disease susceptibility throughout life. However, little is known about the importance of specific nutritional factors.

Objectives

We assessed the impact of multiple maternal nutritional factors on TL in placenta and cord blood.

Methods

In a population-based mother-child cohort in northwestern Argentina, we measured maternal weight, BMI, body fat percentage (BFP), and several nutrients [selenium, magnesium, calcium, zinc, manganese, iodine, vitamin B-12, folate, 25-hydroxycholecalciferol (25(OH)D3)], hemoglobin, and homocysteine in maternal whole blood, serum, plasma, or urine during pregnancy (mean gestational week 27). We measured the rela

SUBMITTER: Vahter M 

PROVIDER: S-EPMC7549303 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature