Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children.

ABSTRACT:

Background & aims

Fecal microbiota transplantation (FMT) is commonly used to treat Clostridium difficile infection (CDI). CDI is an increasing cause of diarrheal illness in pediatric patients, but the effects of FMT have not been well studied in children. We performed a multi-center retrospective cohort study of pediatric and young adult patients to evaluate the efficacy, safety, and factors associated with a successful FMT for the treatment of CDI.

Methods

We performed a retrospective study of 372 patients, 11 months to 23 years old, who underwent FMT at 18 pediatric centers, from February 1, 2004, to February 28, 2017; 2-month outcome data were available from 335 patients. Successful FMT was defined as no recurrence of CDI in the 2 months following FMT. We performed stepwi

SUBMITTER: Nicholson MR 

PROVIDER: S-EPMC7549313 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature