Tubulocystic renal cell carcinoma: a distinct clinicopathologic entity with a characteristic genomic profile.

ABSTRACT: Tubulocystic renal cell carcinoma, a unique tumor, was recently included as a new entity in the World Health Organization classification of renal tumors. It has variably been reported to be related to other renal cell carcinomas, including papillary renal cell carcinoma, fumarate hydratase-deficient carcinoma, and others, likely because many such carcinomas may show variable amounts of tubulocystic architecture. The published data characterizing the molecular features of these tumors are inconsistent. We studied nine "pure" tubulocystic renal cell carcinomas, as defined by International Society of Urologic Pathologists (ISUP) and World Health Organization (WHO), by targeted next-generation sequencing, and fluorescence in situ hybridization for X and Y chromosomes, to investigate if these s

SUBMITTER: Sarungbam J 

PROVIDER: S-EPMC7549436 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature