Modulation of mammalian translation by a ribosome-associated tRNA half.

ABSTRACT: Originally considered futile degradation products, tRNA-derived RNA fragments (tdRs) have been shown over the recent past to be crucial players in orchestrating various cellular functions. Unlike other small non-coding RNA (ncRNA) classes, tdRs possess a multifaceted functional repertoire ranging from regulating transcription, apoptosis, RNA interference, ribosome biogenesis to controlling translation efficiency. A subset of the latter tdRs has been shown to directly target the ribosome, the central molecular machine of protein biosynthesis. Here we describe the function of the mammalian tRNA^Pro 5' half, a 35 residue long ncRNA associated with ribosomes and polysomes in several mammalian cell lines. Addition of tRNA^Pro halves to mammalian in vitro translation s

SUBMITTER: Gonskikh Y 

PROVIDER: S-EPMC7549673 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature