Lipid depletion enables permeation of Staphylococcus aureus bacteria through human stratum corneum.

ABSTRACT: Atopic dermatitis (AD) is a chronic inflammatory disease that affects approximately 2-5% of adults worldwide. The pathogenesis of AD continues to be a well-debated point of conjecture, with numerous hypotheses having been proposed. AD conditions are associated with increased populations of Staphylococcus aureus and reduced skin lipids. In this study, we evaluate the ability of S. aureus to permeate across human stratum corneum (SC) exhibiting both normal and depleted lipid conditions consistent with AD. This permeation would enable bacteria to interact with underlying viable epidermal cells, which could serve as a trigger for inflammation and disease onset. Our results indicate that permeation of S. aureus through SC exhibiting normal lipid conditions is not statistica

SUBMITTER: Lipsky ZW 

PROVIDER: S-EPMC7549745 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature