Recombinant CsHscB of carcinogenic liver fluke Clonorchis sinensis induces IL-10 production by binding with TLR2.

ABSTRACT:

Background

Clonorchis sinensis, a fluke dwelling in the intrahepatic bile ducts causes clonorchiasis, which affect about 15 million people wide-distributed in eastern Asia. During C. sinensis infection, worm-host interaction results in activation of patterns recognition receptors (PRRs) such as Toll-like receptors (TLRs) and further triggers immune responses, which determines the outcome of the infection. However, the mechanisms by which pathogen-associated molecules patterns from C. sinensis interact with TLRs were poorly understood. In the present study, we assumed that the molecules from C. sinensis may regulate host immune responses via TLR2 signaling pathway.

Methodology/principal findings

In the present study, we have identified a ~34 kDa CsHscB from C. sinensis which

SUBMITTER: Yan C 

PROVIDER: S-EPMC7549790 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature