Effects of dabigatran and rivaroxaban on stroke severity according to the results of routine coagulation tests.

ABSTRACT:

Introduction

Prior use of direct oral anticoagulants has been associated with reduced stroke severity in patients with non-valvular atrial fibrillation (NVAF). The aim of this study was to investigate the impact of prothrombin time (PT) and activated partial thromboplastin time (aPTT) on stroke severity in patients who were receiving dabigatran or rivaroxaban at the time of stroke onset.

Materials and methods

We enrolled 107 patients with NVAF who developed acute ischemic stroke while on dabigatran or rivaroxaban and presented within 24 hours to nine hospitals between January 2014 and December 2018. The results of PT and aPTT assays were obtained within 24 hours of stroke onset in all patients. We analyzed PT and aPTT in relation to stroke severity and ischemic lesion volume

SUBMITTER: Cho HJ 

PROVIDER: S-EPMC7549802 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature