Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity.

ABSTRACT: Understanding the genetic regulation of organ structure is a fundamental problem in developmental biology. Here, we use egg-producing structures of insect ovaries, called ovarioles, to deduce systems-level gene regulatory relationships from quantitative functional genetic analysis. We previously showed that Hippo signalling, a conserved regulator of animal organ size, regulates ovariole number in Drosophila melanogaster. To comprehensively determine how Hippo signalling interacts with other pathways in this regulation, we screened all known signalling pathway genes, and identified Hpo-dependent and Hpo-independent signalling requirements. Network analysis of known protein-protein interactions among screen results identified independent gene regulatory sub-networks regulating one or both of

SUBMITTER: Kumar T 

PROVIDER: S-EPMC7550192 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature