Exposure of human fallopian tube epithelium to elevated testosterone results in alteration of cilia gene expression and beating.

ABSTRACT:

Study question

How does exposure to a testosterone rich environment affect the function and gene expression of human fallopian tube epithelium (hFTE)?

Summary answer

Elevated testosterone level alters several gene transcripts that regulate cilia expression and negatively impacts the rate of cilia beating.

What is known already

The presence of estrogen in the follicular phase of the menstrual cycle increases the human fallopian tube ciliary beating frequency. The luteal phase, triggered by ovulation and increasing progesterone, is marked by a decrease in ciliary beating. Women with polycystic ovarian syndrome (PCOS) may have twice the serum level of testosterone than ovulatory women. To date, the effect of elevated androgens on the function of the human fallopian tube

SUBMITTER: Jackson-Bey T 

PROVIDER: S-EPMC7550267 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature