The functional cooperation of 5-HT_1A and mGlu4R in HEK-293 cell line.

ABSTRACT:

Background

The serotonin 5-HT_1A receptor (5-HT_1AR) and metabotropic glutamate receptor 4 (mGlu4) have been implicated as sites of antipsychotic drug action. 5-HT_1AR belongs to the A class of G protein-coupled receptors (GPCRs); mGlu4 is a representative of class C GPCRs. Both receptors preferentially couple with Gi protein to inhibit cAMP formation. The present work aimed to examine the possibility of mGlu4 and 5-HT_1A receptor cross-talk, the phenomenon that could serve as a molecular basis of the interaction of these receptor ligands observed in behavioral studies.

Methods

First, in vitro studies were performed to examine the pharmacological modulation of interaction of the mGlu4 and 5-HT_1A receptors in the T-REx 293 ce

SUBMITTER: Burnat G 

PROVIDER: S-EPMC7550284 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature