Neurotrophic factors for disease-modifying treatments of Parkinson's disease: gaps between basic science and clinical studies.

ABSTRACT:

Background

Neurotrophic factors are endogenous proteins promoting the survival of different neural cells. Therefore, they elicited great interest as a possible treatment for neurodegenerative disorders, including Parkinson's Disease (PD). PD is the second most common neurodegenerative disorder, scientifically characterized more than 200 years ago and initially linked with motor abnormalities. Currently, the disease is viewed as a highly heterogeneous, progressive disorder with a long presymptomatic phase, and both motor and non-motor symptoms. Presently only symptomatic treatments for PD are available. Neurohistopathological changes of PD affected brains have been described more than 100 years ago and characterized by the presence of proteinaceous inclusions known as Lewy bodies an

SUBMITTER: Chmielarz P 

PROVIDER: S-EPMC7550372 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature