Induction of Antigen-Specific Tolerance in T Cell Mediated Diseases.

ABSTRACT: The development of novel approaches to control unwanted immune responses represents an ambitious goal in the management of a number of clinical conditions, including autoimmunity, autoinflammatory diseases, allergies and replacement therapies, in which the T cell response to self or non-harmful antigens threatens the physiological function of tissues and organs. Current treatments for these conditions rely on the use of non-specific immunosuppressive agents and supportive therapies, which may efficiently dampen inflammation and compensate for organ dysfunction, but they require lifelong treatments not devoid of side effects. These limitations induced researchers to undertake the development of definitive and specific solutions to these disorders: the underlying principle of the novel appro

SUBMITTER: Passerini L 

PROVIDER: S-EPMC7550404 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature