Dataset Information

Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8⁺ T Cell Responses but Differ in Capacity to Induce CD4⁺ T Cell Responses and Antibody Responses.

ABSTRACT: Despite extensive research, the development of an effective malaria vaccine remains elusive. The induction of robust and sustained T cell and antibody response by vaccination is an urgent unmet need. Chimeric virus-like particles (VLPs) are a promising vaccine platform. VLPs are composed of multiple subunit capsomeres which can be rapidly produced in a cost-effective manner, but the ability of capsomeres to induce antigen-specific cellular immune responses has not been thoroughly investigated. Accordingly, we have compared chimeric VLPs and their sub-unit capsomeres for capacity to induce CD8⁺ and CD4⁺ T cell and antibody responses. We produced chimeric murine polyomavirus VLPs and capsomeres each incorporating defined CD8⁺ T cell, CD4⁺ T cell or

SUBMITTER: Pattinson DJ

PROVIDER: S-EPMC7550421 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8⁺ T Cell Responses but Differ in Capacity to Induce CD4⁺ T Cell Responses and Antibody Responses.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8⁺ T Cell Responses but Differ in Capacity to Induce CD4⁺ T Cell Responses and Antibody Responses.