Discordance between human sperm quality and telomere length following differential gradient separation/swim-up.

ABSTRACT:

Background

Strong evidence has suggested an important role of telomeres in meiosis, fertilization, and embryo development.

Purpose

To determine if sperm telomere length (STL) in sperm purified by differential gradient centrifugation followed by swim-up (selected STL) is correlated with sperm quality and clinical outcomes.

Methods

Relative selected STL was assessed by quantitative polymerase chain reaction (Q-PCR) in 78 consecutive assisted reproductive technology (ART) treatments during 2017. Statistical analyses were performed in the totality of patients, and in normozoospermic and non-normozoospermic patients. These included correlations between selected STL and sperm quality parameters, embryological parameters (multivariable linear regression), and clinical parame

SUBMITTER: Lopes AC 

PROVIDER: S-EPMC7550483 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature