M⁶A Reader HNRNPA2B1 Promotes Esophageal Cancer Progression via Up-Regulation of ACLY and ACC1.

ABSTRACT: N6-methyladenosine (m⁶A) modification is the most abundant modification on eukaryotic RNA. In recent years, lots of studies have reported that m⁶A modification and m⁶A RNA methylation regulators were involved in cancer progression. However, the m⁶A level and its regulators in esophageal cancer (ESCA) remain poorly understood. In this study, we analyzed the expression of m⁶A regulators using The Cancer Genome Atlas data and found 14 of 19 m⁶A regulators are significantly increased in ESCA samples. Then we performed a univariate Cox regression analysis and LASSO (least absolute shrinkage and selection operator) Cox regression model to investigate the prognostic role of m⁶A regulators in ESCA, and the results indicat

SUBMITTER: Guo H 

PROVIDER: S-EPMC7550530 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature