Early-pregnancy transcriptome signatures of preeclampsia: from peripheral blood to placenta.

ABSTRACT: Several studies have linked maternal asthma, excess BMI, and low vitamin D status with increased risk of Preeclampsia (PE) development. Given prior evidence in the literature and our observations from the subjects in the Vitamin D Antenatal Asthma Reduction Trial (VDAART), we hypothesized that PE, maternal asthma, vitamin D insufficiency, and excess body mass index (BMI) might share both peripheral blood and placental gene signatures that link these conditions together. We used samples collected in the VDAART to investigate relationships between these four conditions and gene expression patterns in peripheral blood obtained at early pregnancy. We identified a core set of differentially expressed genes in all comparisons between women with and without these four conditions and confirmed the

SUBMITTER: Yadama AP 

PROVIDER: S-EPMC7550614 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature