Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia.

ABSTRACT: Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms. In fact, half of schizophrenia cases can be defined as having a "high inflammatory/immune biotype." Recent studies implicate both complement and macrophages in cortical neuroinflammation in schizophrenia. Our aim was to determine whether measures of transcripts related to phagocytosis/macrophages (CD163, CD64, and FN1), or related to macrophage adhesion [intercellular adhesion molecule 1 (ICAM1)], or whether CD163+ cell density, as well as protein and/or gene expression of complement pathway activators (C1qA) and mediators (C3 or C4), are increased in the midbrain in schizophrenia, especially in those with a high inflammatory bioty

SUBMITTER: Purves-Tyson TD 

PROVIDER: S-EPMC7550636 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature