Ethnic and Adipose Depot Specific Associations Between DNA Methylation and Metabolic Risk.

ABSTRACT:

Background

Metabolic risk varies according to body mass index (BMI), body fat distribution and ethnicity. In recent years, epigenetics, which reflect gene-environment interactions have attracted considerable interest as mechanisms that may mediate differences in metabolic risk. The aim of this study was to investigate DNA methylation differences in abdominal and gluteal subcutaneous adipose tissues of normal-weight and obese black and white South African women.

Methods

Body composition was assessed using dual-energy x-ray absorptiometry and computerized tomography, and insulin sensitivity was measured using a frequently sampled intravenous glucose tolerance test in 54 normal-weight (BMI 18-25 kg/m²) and obese (BMI ≥ 30 kg/m²) women. Global and insulin r

SUBMITTER: Pheiffer C 

PROVIDER: S-EPMC7550664 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature