The Early Phase of β2-Microglobulin Aggregation: Perspectives From Molecular Simulations.

ABSTRACT: Protein β2-microglobulin is the causing agent of two amyloidosis, dialysis related amyloidosis (DRA), affecting the bones and cartilages of individuals with chronic renal failure undergoing long-term hemodialysis, and a systemic amyloidosis, found in one French family, which impairs visceral organs. The protein's small size and its biomedical significance attracted the attention of theoretical scientists, and there are now several studies addressing its aggregation mechanism in the context of molecular simulations. Here, we review the early phase of β2-microglobulin aggregation, by focusing on the identification and structural characterization of monomers with the ability to trigger aggregation, and initial small oligomers (dimers, tetramers, hexamers etc.) formed in the so-called nucleati

SUBMITTER: Loureiro RJS 

PROVIDER: S-EPMC7550760 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature