JCAD expression and localization in human blood endothelial cells.

ABSTRACT:

Background

Junctional Cadherin 5 Associated (JCAD) is an endothelial, cell-cell junction protein, and its expression is associated with cardiovascular diseases including atherosclerosis and hypertension. However, to date, there are few studies confirming JCAD expression and precise localization in human tissues by immunohistochemical staining.

Methods

JCAD expression and localization was assessed in four human submandibular gland (SMG) specimens by immunohistochemical staining. One specimen of SMG with sialoadenitis was accompanied by severe inflammation and fibrosis, while the other was largely normal. Other two SMGs were accompanied by severe fibrosis because of irradiation.

Results

Immunohistochemical analysis of human SMGs revealed JCAD localization at the blood e

SUBMITTER: Shigeoka M 

PROVIDER: S-EPMC7550929 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature