Prognosis of Cryptogenic Stroke With Patent Foramen Ovale at Older Ages and Implications for Trials: A Population-Based Study and Systematic Review.

ABSTRACT:

Importance

Patent foramen ovale (PFO) closure may prevent recurrent stroke after cryptogenic transient ischemic attack (TIA) or stroke (TIA/stroke) in patients aged 60 years or younger. Patent foramen ovale is associated with cryptogenic stroke in the older population, but risk of recurrence is unknown. Data on prognosis of patients receiving medical treatment at older ages (≥60 years) are essential to justify trials of PFO closure.

Objective

To examine the age-specific risk of recurrence in patients with cryptogenic TIA/stroke with PFO.

Design, setting, and participants

A prospective study was nested in the population-based Oxford Vascular Study between September 1, 2014, and March 31, 2019, with face-to-face follow-up for 5 years. A total of 416 consecutive patients

SUBMITTER: Mazzucco S 

PROVIDER: S-EPMC7550974 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature