A Clinical Tool to Predict Low Serum Selenium in Patients with Worsening Heart Failure.

ABSTRACT: Selenium is an essential micronutrient, and a low selenium concentration (<100 µg/L) is associated with a poorer quality of life and exercise capacity, and an impaired prognosis in patients with worsening heart failure. Measuring selenium concentrations routinely is laborious and costly, and although its clinical utility is yet to be proven, an easy implemented model to predict selenium status is desirable. A stepwise multivariable logistic regression analysis was performed using routinely measured clinical factors. Low selenium was independently predicted by: older age, lower serum albumin, higher N-terminal pro-B-type natriuretic peptide levels, worse kidney function, and the presence of orthopnea and iron deficiency. A 10-points risk-model was developed, and a score of ≥6 points identif

SUBMITTER: Al-Mubarak AA 

PROVIDER: S-EPMC7551091 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature